RESEARCH OVERVIEW

We work to understand synaptic transmission in the central nervous system through rigorous and systematic scientific research, that results in impactful scholarly publications, and exceptionally trained scientists. We focus our research on NMDA receptors because their characteristic biophysical properties, which are under complex regulation, affect directly and in important ways synaptic function and dysfunction.

NMDA receptors are the most abundant glutamate-gated Ca²⁺-conducting channels in brain and spinal cord; they have critical control over synaptic development and plasticity; and their dysfunction or dysregulation correlates with severe neuropathies and psychiatric disorders. Over the past 10 years, our NINDS- and AHA-funded work has helped to delineate the NMDA receptor reaction mechanism and the principles of its allosteric modulation by soluble endogenous and pharmacologic ligands. This research resulted in numerous publications and introduced new concepts necessary to address in a rigorous and mechanistic manner the mechanisms of activity-dependent control of NMDA receptor signals.

Along with research and scholarship, my lab represents a fertile ground for the training of junior scientists. I was fortunate to work with, and in the process to develop and train four talented postdocs, ten graduate students (eight PhD and two MS) and numerous undergraduate students; many of my trainees have been recognized with awards (NIH fellowships, presidential scholarships, travel awards) and some have already obtained permanent positions in academia or industry. Two accomplished colleagues have done research in my lab while on sabbatical leave from their institutions.

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